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Illustration for Can emerging bisphenol replacements cross the placenta and trigger preterm birth?

Can emerging bisphenol replacements cross from mother to baby?

Based on 1 peer-reviewed studybaby
Verdict: Some Concern

Use caution with BPA-free products that still use bisphenol replacement chemistry during pregnancy.

What's actually in it

Bisphenol alternatives are chemicals used to replace BPA in some consumer products. Examples in the 2026 study included TGSA and BPS-MPE, along with BPA and other analogues.

The label BPA-free does not always mean bisphenol-free. That matters during pregnancy because some bisphenol chemicals can move from mother to baby.

What the research says

A 2026 study in Environ Toxicol Pharmacol analyzed first urine samples from 90 newborns in Southern China. More than 95% of samples contained 2 to 11 bisphenols, which supports maternal-fetal transfer and mixed exposure.

TGSA was detected in many samples and had a transplacental transfer efficiency above 1. The study also found TGSA was associated with higher odds of iatrogenic preterm birth, with an odds ratio of 7.90 and a wide 95% confidence interval from 1.22 to 51.3. That is a signal, not proof that one product causes preterm birth.

Practical move: during pregnancy, use glass for food storage and avoid heating food in plastic. For receipts and food-contact plastic, BPA-free is not enough unless the brand explains the replacement chemistry.

What to use instead

Browse our curated non-toxic alternatives. Every product is third-party certified.

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